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- Title
Antigenotoxic Effect of Curcumin and Carvacrol against Parathion Induced DNA Damage in Cultured Human Peripheral Blood Lymphocytes and Its Relation to GSTM1 and GSTT1 Polymorphism.
- Authors
Kumar, Neeraj; Yadav, Anita; Gulati, Sachin; Kanupriya; Aggarwa, Neeraj; Gupta, Ranjan
- Abstract
In recent years, the use of organophosphorus pesticides has been extensively increased and these compounds signify a major class of agricultural pesticides today. We studied antigenotoxic potential of curcumin and carvacrol against the parathion induced DNA damage in cultured peripheral blood lymphocytes using sister chromatid exchanges as a biomarker of genotoxicity. Heparinised fresh blood fromhealthy individuals was treated with 2.5 µg/mL concentration of parathion in presence of curcumin and carvacrol in order to observe the antigenotoxic potential of both curcumin and carvacrol. Significant reduction (P < 0.05) was observed in the frequencies of SCEs in presence of 10 µg/mL and 15 µg/mL concentrations of curcumin as compared to parathion exposed sample. Similarly carvacrol had significant (P < 0.05) antigenotoxic effect at the concentrations of 2.5 µg/mL and 5.0 µg/mL against the parathion. We also studied the effect of GSTT1 and GSTM1 on genotoxicity of parathion and antigenotoxic potential of curcumin and carvacrol. We did not observe any significant effect (P > 0.05) of GSTT1 and GSTM1 polymorphism on genotoxicity of parathion and antigenotoxic potential of curcumin and carvacrol.
- Subjects
GENETIC toxicology; CURCUMIN; CARVACROL; PARATHION; DNA damage; LYMPHOCYTES; GLUTATHIONE transferase; GENETIC polymorphisms; THERAPEUTICS
- Publication
Journal of Toxicology, 2014, p1
- ISSN
1687-8191
- Publication type
Article
- DOI
10.1155/2014/404236