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- Title
Cobalamin Deficiency in Elderly Patients: A Personal View.
- Authors
Andrès, Emmanuel; Vogel, Thomas; Federici, Laure; Zimmer, Jacques; Ciobanu, Ecaterina; Kaltenbach, Georges
- Abstract
Cobalamin (vitamin B12) deficiency is particularly common in the elderly (>65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly froma neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to Helicobacter pylori infection, and longterm ingestion of antacids and biguanides. Management of cobalamin deficiency with cobalamin injections is currently well documented but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption.
- Subjects
DISEASES in older people; ANTACIDS; VITAMIN B12; CORRINOIDS; ANEMIA; BLOOD diseases; LEUKEMIA; GERIATRICS; GASTRITIS
- Publication
Current Gerontology & Geratrics Research, 2008, p1
- ISSN
1687-7063
- Publication type
Article
- DOI
10.1155/2008/848267