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- Title
Partially Reversible Immunodeficiency After In-Utero Exposure to Immunosuppressants.
- Authors
Gössling, Katharina L.; Kobbe, Robin; Boetticher, Benedikt; Soura, Stavrieta; Borkhardt, Arndt; Wittkowski, Helmut; Schwab, Matthias; Kobbe, Guido; Neubert, Jennifer; Ghosh, Sujal; Laws, Hans-Jürgen; Oommen, Prasad Thomas
- Abstract
Treatment with immunosuppressants affects pregnant women too. The European League Against Rheumatism (EULAR) has published recommendations for action for the use of immunosuppressants in pregnancy; azathioprine (n=72) and rituximab (n=256) were not associated with increased rates of miscarriage or malformations (1). But long term data on the effects on children's immune reconstitution after exposure to these substances are lacking (2). We report on three cases of exposure to rituximab or azathioprine in utero that led to partly reversible, partly sustained immunodeficiency.
- Subjects
IMMUNOSUPPRESSIVE agents; IMMUNODEFICIENCY; PREGNANT women; AZATHIOPRINE; RITUXIMAB
- Publication
Deutsches Ärzteblatt International, 2023, Vol 120, Issue 46, p3
- ISSN
1866-0452
- Publication type
Article