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- Title
Syntheses of 4-Substituted 2-(Trichloromethyl)quinazolines under Mild Conditions by Benzyne [4+2] Cycloaddition.
- Authors
Lechuga‐Eduardo, Harim; Olivo, Horacio F.; Romero‐Ortega, Moises
- Abstract
An experimentally simple and convenient synthesis of 4-susbstituted 2-(trichloromethyl)quinazolines by cycloaddition of benzyne with 2-(trichloromethyl)-1,3-diazabutadienes was developed. The 2-(trichloromethyl)-1,3-diazabutadienes (R1 = H and Me) were prepared from trichloroacetamidine and the appropriate N, N-dimethylamide dimethyl acetal or from trichloroacetamidine and a Vilsmeier-Haack reagent containing an aryl group.
- Subjects
TRICHLOROMETHYL group; FREE radicals; RING formation (Chemistry); VILSMEIER reagents; ARYL group
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 27, p5910
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201402706