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- Title
Association Between Steroid Use and Nephropathy in Patients Who Were Administered a Proton Pump Inhibitor: Analysis of the Japanese Adverse Event Report Database.
- Authors
Mitsuboshi, Satoru; Kaseda, Ryohei; Narita, Ichiei
- Abstract
This study used the Japanese Adverse Drug Event Report database to investigate whether steroid use decreases the risk of nephropathy in patients who were administered a proton pump inhibitor (PPI). Disproportionality of kidney injury was observed between patients who did and those who did not use steroids while taking lansoprazole (reporting odds ratio, 0.78; 95% confidence interval [CI], 0.65‐0.93; P =.002) or rabeprazole (reporting odds ratio, 0.69; 95%CI, 0.53‐0.89; P =.005). Multiple logistic regression analysis revealed a significantly negative association of kidney injury with steroid use (odds ratio [OR], 0.85; 95%CI, 0.75‐0.96; P =.011) and a significantly positive association with the presence of chronic kidney disease (OR, 1.66; 95%CI, 1.44‐1.90; P <.001), the presence of comorbidities that relate to nephropathy (OR, 1.43; 95%CI, 1.29‐1.59; P <.001), male sex (OR, 1.25; 95%CI, 1.13‐1.39; P <.001), and age ≥80 years (OR, 1.21; 95%CI, 1.07‐1.37; P =.002). These findings suggest that steroid use may decrease the risk of proton pump inhibitor–induced nephropathy.
- Subjects
KIDNEY disease risk factors; STEROID drugs; STATISTICAL significance; SCIENTIFIC observation; CONFIDENCE intervals; MULTIPLE regression analysis; KIDNEY diseases; PROTON pump inhibitors; RISK assessment; LANSOPRAZOLE; DESCRIPTIVE statistics; DRUG side effects; DATA analysis software; ODDS ratio; COMORBIDITY
- Publication
Journal of Clinical Pharmacology, 2022, Vol 62, Issue 2, p272
- ISSN
0091-2700
- Publication type
Article
- DOI
10.1002/jcph.1964