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- Title
Correlation Between Thyroid Disorders and Rate of Helicobacter Pylori Infection.
- Authors
Mokhtariye, Armin; Pouresmaeil, Omid; Baledi, Fatemeh; Marzban, Sima; Ghavidel, Farideh; Derafsheh, Aref; Vosoughi, Mahdieh; Keyfi, Fatemeh
- Abstract
Background: Hyperthyroidism and hypothyroidism are common thyroid disorders. Thyroid hormones have a great role in regulating mucosal cells and the growth of the gastrointestinal tract. In this study, we investigated the presence of Helicobacter pylori (H. pylori) infection in various types of thyroid disorders. Materials and Methods: Our study included 297 patients whose thyroid status was identified by evaluation of thyroid hormones; triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) using Roche Electrochemiluminescence (ECL). H. pylori antibodies and antigen were evaluated by enzyme-linked immunosorbent assay (ELISA) kits in all cases. Results: Hypothyroidism had a significant correlation with H. pylori infection (p < 0.001). Hyperthyroidism was not related to H. pylori infection (p = 0.171). Also, in hypothyroidism, female sex more than male sex had a significant correlation with H. pylori infection (p = 0.004). Conclusion: Decreasing thyroid hormones can result in dysregulation of gastric mucosal cells, therefore hypothyroidism can lead to more chance of having H. pylori infection.
- Subjects
BACTERIAL antigens; CHEMILUMINESCENCE assay; ELECTROCHEMICAL analysis; ENZYME-linked immunosorbent assay; GASTRIC mucosa; HELICOBACTER diseases; HELICOBACTER pylori; HYPERTHYROIDISM; HYPOTHYROIDISM; RISK assessment; SEX distribution; THYROID diseases; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE; BACTERIAL antibodies; DISEASE complications; DISEASE risk factors
- Publication
Iranian Journal of Gastroenterology & Hepatology (GOVARESH), 2020, Vol 24, Issue 4, p238
- ISSN
1560-7186
- Publication type
Article