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- Title
Vicissitudes in polyphenolic extract-based high internal phase creams (HIPCs)-effect of storage temperature dependent characteristics.
- Authors
Ali, Atif; Akhtar, Naveed; Khan, Hira; Jamil, Qazi Adnan; Shah, Sajid Hussain; Naeem, Muhammad; Asad, Muhammad Hassham Hassan Bin
- Abstract
The purpose of this investigation was to evaluate the vicissitudes in polyphenolic extract-based high internal phase creams (HIPCs) and effect of storage temperature dependent characteristics. Rheological parameters, that is, power law and IPC analysis with its physical characteristics were exploredat different storage temperatures (8°, 25°, 40° and 40° with 75% relative humidity-RH) with different time intervals up to 2 months of newly formulated poly-phenolic extract-based high internal phase cream and its comparison with base. Polyphenolic-based HIPCs showed non-Newtonian-pseudo plastic tendencies in vicissitudes with time and storage temperatures. Data analysis with Power Law and IPC paste was found to fit to all the rheograms. Flow index, shear sensitivity factor, consistency Index and 10 RPM of freshly prepared HIPCs with and without encapsulated polyphenolic extract were found to be 0.5,0.53, 386.4 cP, and 432.9 cP, respectively. The viscosities were fallen with rise in shear stress. There was no change in color, electrical conductivity, liquefaction and phase separation after centrifugation in any sample of polyphenolic extract-based HIPCs and its base. Polyphenolic-based extract HIPCs behaved non-Newtonian-pseudo plastic tendencies and showed stability up to 2 months and can be directed absolutely to shield skin against ultraviolet radiation (UV) intervened oxidative mutilation.
- Subjects
DEBYE temperatures; SHEARING force; ULTRAVIOLET radiation; ELECTRIC conductivity; PHASE separation; OINTMENTS
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2020, Vol 33, Issue 6, p2521
- ISSN
1011-601X
- Publication type
Article
- DOI
10.36721/PJPS.2020.33.6.REG.2521-2526.1