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- Title
Estimation of yohimbine base in complex mixtures by quantitative HPTLC application.
- Authors
Adel-Kader, Maged Saad; Alwahebi, Naif Wahebi Hamadan; Alam, Prawez
- Abstract
The indole alkaloid Yohimbine has been used for over two centuries in the treatment of erectly dysfunction. Several formulations containing yohimbine salts, yohimbe bark power or extract are marketed worldwide. Determination of the amount of yohimbine in such formulation is a challenging task due to their complex nature. Extraction followed by acid-base purification resulted in a relatively pure alkaloids containing fractions. The exact amounts of yohimbine free base in different formulations were determined by densitometric HPTLC validated methods using silica gel TLC plates. Standard curve for yohimbine was generated using yohimbine hydrochloride subjected to the same acid-base treatment as the used samples. All formulations found to contain yohimbine though some with less concentration than the labeled amount.
- Subjects
YOHIMBINE; IMPOTENCE; TREATMENT of sexual dysfunction; HIGH performance liquid chromatography; SILICA gel; THERAPEUTIC use of plant extracts; THERAPEUTICS
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2017, Vol 30, Issue 1, p149
- ISSN
1011-601X
- Publication type
Article