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- Title
Propranolol use in patients with cirrhosis and refractory ascites: A nationwide study.
- Authors
Chen, Yen-Chun; Li, Yun-Da; Lu, Chia-Ming; Huang, Wei-Chun; Kao, Sung-Shuo; Chen, Wen-Chi
- Abstract
Background: The impact of propranolol on patients with cirrhosis and refractory ascites is controversial. We conducted a nationwide longitudinal cohort study to compare the survival between patients with cirrhosis and refractory ascites, with and without using propranolol. Methods: Data of patients with cirrhosis and refractory ascites using propranolol, and controls matched by age and gender, were extracted from The National Health Insurance Research Database of Taiwan. The baseline demographic characteristics were compared between groups. Cox regression analysis was used to examine the predictors of mortality. Results: In this study, 1788 patients were enrolled in each group; 1304 patients (72.9%) in the propranolol group and 1445 patients (80.8%) in the control group died (P < 0.001). The mean survival was 34.3 ± 31.2 months in the propranolol group and 20.8 ± 26.6 months in the control group (P < 0.001). Propranolol (hazard ratio [HR]: 0.60, 95% confidence interval [CI]: 0.55–0.64, P < 0.001), statins (HR: 0.43, 95% CI: 0.34–0.56, P < 0.001), age (HR: 1.02, 95% CI: 1.01–1.02, P < 0.001), and diabetes mellitus (HR: 1.14, 95% CI: 1.05–1.24, P = 0.002) were the independent predictors for mortality. Conclusions: Use of propanolol was associated with reduced mortality, compared with controls, in this nationwide cohort of patients with cirrhosis and refractory ascites.
- Subjects
TAIWAN; MORTALITY risk factors; STATINS (Cardiovascular agents); PROPRANOLOL; CONFIDENCE intervals; AGE distribution; CIRRHOSIS of the liver; DRUG resistance; DIABETES; ASCITES; DISEASE relapse; RISK assessment; TREATMENT effectiveness; LONGITUDINAL method; PROPORTIONAL hazards models
- Publication
Saudi Journal of Gastroenterology, 2022, Vol 28, Issue 2, p108
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/sjg.sjg_586_21