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- Title
Duration of breastfeeding is associated with improved neurodevelopmental outcomes in survivors of twin-twin transfusion syndrome.
- Authors
Mirzaian, Christine B.; Vanderbilt, Douglas L.; Mamey, Mary Rose; Chmait, Ramen H.; Schrager, Sheree M.
- Abstract
Introduction: Survivors of twin gestations that are complicated by twin-twin transfusion syndrome (TTTS) are at high risk for neurodevelopmental morbidities and there is little known about the benefits of breastmilk in this population. Aim: This study aims to evaluate the effects of breastfeeding on neurodevelopmental outcomes among twins treated with laser surgery for twin-twin transfusion syndrome (TTTS]. Design, setting and participants: This was a retrospective cohort study based at a large urban children's hospital in Los Angeles, California. Participants were twins with TTTS treated with laser surgery. Sample size was 99 subjects. Neurodevelopment at 24 months (+/- 6 weeks) was assessed using the Battelle Developmental Inventory, Second Edition (BDI-2). Independent variables including duration of breastfeeding or providing pumped breastmilk, use of formula, educational level of mother, additional demographic factors and birth weight were collected. Multilevel linear regression analysis was performed to determine factors associated with BDI-2 Total Score. Key findings: In multivariate analysis, longer length of time spent breastfeeding or providing pumped breastmilk ((3=0.37, p=0.013), higher birth weight ((3=0.34, p=0.001) and higher levels of maternal education ((3=0.54, p=0.001) were significantly associated with higher BDI-2 Total Score at 2 years of age. Conclusions and future implications: Infants with TTTS who breastfed or received pumped breastmilk for a longer duration of time demonstrated significantly higher neurodevelopmental scores. Breastfeeding interventions may help offset neurodevelopmental risks for this vulnerable population.
- Subjects
CALIFORNIA; BREAST milk; DEVELOPMENTAL disabilities; BREASTFEEDING; CONFIDENCE intervals; MEDICAL lasers; MULTIVARIATE analysis; QUESTIONNAIRES; REGRESSION analysis; RESEARCH funding; STATISTICS; T-test (Statistics); TWINS; TREATMENT effectiveness; RETROSPECTIVE studies; FETOFETAL transfusion; DATA analysis software; DESCRIPTIVE statistics; SURGERY; THERAPEUTICS; DISABILITIES
- Publication
Breastfeeding Review, 2018, Vol 26, Issue 2, p29
- ISSN
0729-2759
- Publication type
Article