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- Title
Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration.
- Authors
Sutcliffe, S.; Nevin, R L; Pakpahan, R; Elliott, D J; Cole, S R; De Marzo, A M; Gaydos, C A; Isaacs, W B; Nelson, W G; Sokoll, L J; Zenilman, J M; Cersovsky, S B; Platz, E A
- Abstract
<bold>Background: </bold>We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members.<bold>Methods: </bold>We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls.<bold>Results: </bold>Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P<0.0001, 0.021, and 0.92, respectively).<bold>Conclusion: </bold>Chlamydia and gonorrhoea may infect the prostate of some infected men.
- Subjects
SEXUALLY transmitted diseases; PROSTATE; PROSTATE-specific antigen; NONGONOCOCCAL urethritis; CHLAMYDIA; PROSTATE physiology; EPIDEMIOLOGY of sexually transmitted diseases; RESEARCH; GONORRHEA; RESEARCH methodology; CASE-control method; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; OSMOLAR concentration; CHLAMYDIA infections; MILITARY personnel; INFECTIOUS disease transmission
- Publication
British Journal of Cancer, 2011, Vol 105, Issue 5, p602
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/bjc.2011.271