We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a, and Photofrin ® in Different Conditions.
- Authors
Myrzakhmetov, Bauyrzhan; Arnoux, Philippe; Mordon, Serge; Acherar, Samir; Tsoy, Irina; Frochot, Céline; Frija, Luís M. T.
- Abstract
Photodynamic therapy (PDT) is an innovative treatment of malignant or diseased tissues. The effectiveness of PDT depends on light dosimetry, oxygen availability, and properties of the photosensitizer (PS). Depending on the medium, photophysical properties of the PS can change leading to increase or decrease in fluorescence emission and formation of reactive oxygen species (ROS) especially singlet oxygen (1O2). In this study, the influence of solvent polarity, viscosity, concentration, temperature, and pH medium on the photophysical properties of protoporphyrin IX, pyropheophorbide-a, and Photofrin® were investigated by UV-visible absorption, fluorescence emission, singlet oxygen emission, and time-resolved fluorescence spectroscopies.
- Subjects
TIME-resolved spectroscopy; REACTIVE oxygen species; PHOTODYNAMIC therapy; FLUORESCENCE spectroscopy
- Publication
Pharmaceuticals (14248247), 2021, Vol 14, Issue 2, p138
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph14020138