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- Title
Mechanisms of Constitutive Activation of Janus Kinase 2-V617F Revealed at the Atomic Level Through Molecular Dynamics Simulations.
- Authors
Tai-Sung Lee; Wanlong Ma; Xi Zhang; Giles, Francis; Kantarjian, Hagop; Albitar, Maher
- Abstract
The article presents a study examining the constitutive activation mechanisms of Janus kinase 2 (JAK2)-V617F. Methods used in the study were molecular dynamics simulation techniques. In the conducted analysis, results show the consistency of JAK2 autoregulation mechanism with experimental evidence which may have the possibility of greater understanding of JAK2 and other kinase systems.
- Subjects
FOCAL adhesion kinase; MOLECULAR dynamics; NUCLEAR activation analysis; WAVE mechanics; SIMULATION methods &; models
- Publication
Cancer (0008543X), 2009, Vol 115, Issue 8, p1692
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.24183