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- Title
薑黃素自乳化液配方、載量及釋放特性評估.
- Authors
巫定亞; 江伯源
- Abstract
Curcumin, a nutrition material, is known for its health ingredients in recent years. There are many research have already confirmed that it content a various benefits for human health. However, the application of curcumin is still limited due to its low water solubility, low bioavailability and low stability. Therefore, how to improve its solubility, bioavailability and stability is an critical research direction to the related scientist. The subject of the study; self-emulsifying delivery system (SEDS) is a lipid-based carrier that increases the solubility, bioavailability and stability of poorly water-soluble components. In this study, we planned to mix the different oils, surfactants and co-surfactant to find out the self-emulsifying formulation with the highest oil and curcumin content, which is through detecting spontaneity, homogeneity and dispersibility of SEDS, Furthermore, it is necessary to investigate the effect of the product quality by using different curcumin loading on the quality of SEDS and the releasing contents of curcumin in the simulated gastrointestinal tract. The results show that Sorbitan monooleate(Span 80) has the best miscibility with algae oil, sunflower oil, olive oil and palm oil; the formulation with higher percentage of POE(20) Sorbitan Monooleate (Tween 80) have the best spontaneity, homogeneity and dispersibility; Tween 80 and Span 80 at a ratio of 1 : 1 as a surfactant formulation can have the product at the highest oil loading, and it can be mixed with palm oil to achieve the highest oil load 66% and the minimum particle size of 267.7 nm; In this formulation, the solubility of curcumin can be up to 6.37 mg/mL. In addition, adding different curcumin contents-3, 4.5 and 6 m/mL-to this SEDS formulation can be find that the increasing particle size and turbidity is correlated with the increase of curcumin loading. Also when we loaded 6 mg curcumin in the formulation, there will be the maximum particle size of 334.0 nm. In the simulated gastrointestinal release test, the release contents percentage of curcumin in simulated gastric fluid and intestinal fluid is about 69 and 80% respectively. In the follow-up research, we’ll focus on how to reduce the release of curcumin in the stomach.
- Publication
Taiwanese Journal of Agricultural Chemistry & Food Science, 2019, Vol 57, Issue 3, p154
- ISSN
1605-2471
- Publication type
Article
- DOI
10.6578/TJACFS.201906_57(3).0005