We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The prevention strategies of swine viruses related to xenotransplantation.
- Authors
Mao, Hongzhen; Li, Jinyang; Liao, Guangneng; Gao, Mengyu; Yang, Guang; Bao, Ji
- Abstract
Xenotransplantation is considered a solution for the shortage of organs, and pigs play an indispensable role as donors in xenotransplantation. The biosecurity of pigs, especially the zoonotic viruses carried by pigs, has attracted attention. This review introduces several viruses, including porcine endogenous retroviruses that are integrated into the pig genome in a DNA form, herpesviruses that have been proven to clearly affect recipient survival time in previous xenotransplant surgeries, the zoonotic hepatitis E virus, and the widely distributed porcine circoviruses. The detail virus information, such as structure, caused diseases, transmission pathways, and epidemiology was introduced in the current review. Diagnostic and control measures for these viruses, including detection sites and methods, vaccines, RNA interference, antiviral pigs, farm biosecurity, and drugs, are discussed. The challenges faced, including those posed by other viruses and newly emerged viruses, and the challenges brought by the modes of transmission of the viruses are also summarized.
- Subjects
HERPESVIRUSES; RETROVIRUSES; XENOTRANSPLANTATION; RNA interference; HEPATITIS E virus; ENDOGENOUS retroviruses; SWINE farms; SWINE; POULTRY farms
- Publication
Virology Journal, 2023, Vol 20, Issue 1, p1
- ISSN
1743-422X
- Publication type
Article
- DOI
10.1186/s12985-023-02090-3