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- Title
Morphological Changes of Intercellular Junctions in the Rat Submandibular Gland Treated by Long-term Repeated Administration of Isoproterenol.
- Authors
INOUE, T.; YAMANE, H.; YAMAMURA, T.; SHIMONO, M.
- Abstract
Long-term repeated administration of isoproterenol (IPR) 2 mg/100 g bw, once daily for ten days, resulted in morphological changes in the intercellular junctions of rat submandibular glands, which were investigated by means of the freeze-fracture technique. A significantly increased number of tight-junctional strands was present. These junctional strands extended much deeper toward the basal membrane than those in normal acinar cells. The basal frontier strands that branched from the networks of tight junctions were elongated and had either free-endings or terminal loops, which were more frequently observed in the IPR-treated acinar cells than in untreated acinar cells. Some of the strands of tight junctions were connected to small gap junctions. The diameters of gap junctions were not significantly different from those of control acinar cells. However, smooth areas devoid of particles were found intermingling with the usual packed particles in irregularly shaped small gap junctions. There was no significant difference between the desmosomes of IPR-treated and untreated acinar cells, in terms of either morphology or distribution. These changes in functional morphology in the IPR-treated acinar cells resemble those seen in salivary glands during development, and in some experimental conditions including timorous changes.
- Subjects
CELL junctions; MORPHOLOGY; SUBMANDIBULAR gland; LABORATORY rats; ISOPROTERENOL; FREEZE fracturing
- Publication
Journal of Dental Research, 1987, Vol 66, Issue 8, p1303
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/00220345870660080301