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- Title
Study on Synthesis and Biological Activity of Some Pyridopyridazine Derivatives.
- Authors
Akçay, Sevilay; Ülger, Mahmut; Onurdağ, Fatma Kaynak; Dündar, Yasemin
- Abstract
In this study, new pyrido[3,4-d]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl) pyrido[3,4-d]pyridazin-4(3H)-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus.
- Subjects
CHEMICAL synthesis; PYRIDAZINES; GRAM-positive bacteria; GRAM-negative bacteria; ISONIAZID; TUBERCULOSIS treatment
- Publication
Acta Chimica Slovenica, 2018, Vol 65, Issue 4, p932
- ISSN
1318-0207
- Publication type
Article
- DOI
10.17344/acsi.2018.4590