We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Palladium-Catalyzed Asymmetric Benzylic Alkylation of Active Methylene Compounds with α-Naphthylbenzyl Carbonates and Pivalates.
- Authors
Tabuchi, Sho; Hirano, Koji; Miura, Masahiro
- Abstract
A Pd/( R)-H8-BINAP-catalyzed asymmetric benzylic alkylation of active methylene compounds has been developed. The reaction proceeds without the use of an external base, and the starting racemic diarylmethyl carbonates are converted into the optically active coupling products which contain the benzylic chiral stereocenter by a dynamic kinetic asymmetric transformation (DYKAT). Additionally, with suitable carbonates bases, the same palladium catalysis allows the corresponding pivalates to be adopted in the same DYKAT process.
- Subjects
PALLADIUM catalysts; ASYMMETRIC synthesis; BENZYLIC group; ALKYLATION; CARBENE synthesis; BENZENE compound synthesis; NAPHTHYL compounds; CARBONATE synthesis
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 24, p7087
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201602075