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- Title
Enzyme- and Ruthenium-Catalyzed Enantioselective Transformation of α-Allenic Alcohols into 2,3-Dihydrofurans.
- Authors
Yang, Bin; Zhu, Can; Qiu, Youai; Bäckvall, Jan‐E.
- Abstract
An efficient one-pot method for the enzyme- and ruthenium-catalyzed enantioselective transformation of α-allenic alcohols into 2,3-dihydrofurans has been developed. The method involves an enzymatic kinetic resolution and a subsequent ruthenium-catalyzed cycloisomerization, which provides 2,3-dihydrofurans with excellent enantioselectivity (up to >99 % ee). A ruthenium carbene species was proposed as a key intermediate in the cycloisomerization.
- Subjects
RUTHENIUM; ENZYMES; CYCLOISOMERIZATION; DIHYDROFURANS; CARBENES
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 18, p5658
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201601505