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- Title
Heteroatom-embedded Medium-Sized Cycloalkynes: Concise Synthesis, Structural Analysis, and Reactions.
- Authors
Ni, Runyan; Mitsuda, Naoto; Kashiwagi, Takeru; Igawa, Kazunobu; Tomooka, Katsuhiko
- Abstract
A variety of medium-sized cycloalkynes were efficiently synthesized by the double Nicholas reaction of cobalt complex and bis(hetero)substituted acyclic compound. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Furthermore, preparation of multifunctionalized alkynes was achieved by embedding the cycloalkyne within a peptide chain.
- Subjects
CYCLOALKYL group; COBALT; RING formation (Chemistry); ALKYNES; PEPTIDES
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 4, p1206
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201409910