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- Title
Controlled Chemical Derivatisation of Carbon Nanotubes with Imaging, Targeting, and Therapeutic Capabilities.
- Authors
Ménard ‐ Moyon, Cécilia; Ali ‐ Boucetta, Hanene; Fabbro, Chiara; Chaloin, Olivier; Kostarelos, Kostas; Bianco, Alberto
- Abstract
In drug delivery, carbon nanotubes (CNTs) hold a great potential as carriers because of their ability to easily cross biological barriers and be internalised into cells. Their high aspect ratio allows multi-functionalisation and their development as a multimodal platform for targeted therapy. In this article, we report the controlled covalent derivatisation of triple-functionalised CNTs with the anticancer drug gemcitabine, folic acid as a targeting ligand and fluorescein as a probe. The anticancer activity of gemcitabine was maintained after covalent grafting onto the CNTs. The functionalised nanotubes were internalised into both folate-positive and negative cells, suggesting the passive diffusion of CNTs. Overall, our approach is versatile and offers a precise chemical control of the sidewall functionalisation of CNTs and the possibility to manoeuvre the types of functionalities required on the nanotubes for a multimodal therapeutic strategy.
- Subjects
CARBON nanotubes; NANOSTRUCTURED materials; DRUG delivery systems; PHARMACEUTICAL technology; FOLIC acid
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 42, p14886
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201501993