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- Title
Development of monovalent ions in the endolymph in mouse cochlea.
- Authors
Yamasaki, Masayuki; Komune, Shizuo; Shimozono, Masami; Matsuda, Keiji; Haruta, Atsushi; Yamasaki, M; Komune, S; Shimozono, M; Matsuda, K; Haruta, A
- Abstract
The present study was designed to clarify the chronological developmental process of monovalent ions (Na(+), K(+), Cl(-)) in the endolymph of the mouse in relation to the development of the endocochlear potential (EP). The EP and ionic concentrations were measured simultaneously with the ion-sensitive double-barreled microelectrodes from the scala media of the basal turn. The EP increased abruptly 7 days after birth (DAB) and reached approximately 80 mV 14 DAB. In the earliest postnatal days, the endolymphatic Na(+) concentration was significantly higher than that in adult mice, however, the K(+) and the Cl(-) concentrations were lower. The concentrations of all the monovalent ions in endolymph reached adult levels at 7 DAB when the EP was still under 20 mV. These data strongly suggest the presence of a different mechanism between the production of monovalent ions, especially of high K(+) in the endolymph and that of EP.
- Subjects
POTASSIUM metabolism; SODIUM metabolism; ADENOSINE triphosphatase; AGAR; ANIMAL experimentation; ANIMAL populations; BIOLOGICAL transport; CHLORIDES; COCHLEA; ELECTROPHORESIS; MICE; POLYMERASE chain reaction; REVERSE transcriptase polymerase chain reaction; ENDOLYMPH
- Publication
ORL, 2000, Vol 62, Issue 5, p241
- ISSN
0301-1569
- Publication type
journal article
- DOI
10.1159/000027753