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- Title
Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families.
- Authors
Freedman, B.; Rich, S.; Sale, M.; Heiss, G.; Djoussé, L.; Pankow, J.; Province, M.; Rao, D.; Lewis, C.; Chen, Y.; Beck, S.
- Abstract
Aims/hypothesis: The heritability of fasting serum insulin and glucose concentrations in non-diabetic members of multiplex hypertensive families is unknown. Methods: We calculated the familial aggregation of fast- ing serum glucose and insulin concentrations and performed a genome -wide scan to assess whether quantitative trait loci contribute to these phenotypes in 2,412 non-diabetic individuals from 1,030 families enrolled in the Hypertension Genetic Epidemiology Network (HyperGEN) in the Family Blood Pressure Program. Results: The heritability (±SE) of fasting serum insulin was 0.47±0.08 5 in European Americans and 0.28±0.08 in African Americans (p<0.0001 for both), after adjusting for age, sex, and BMI. A genome- wide scan for fasting serum insulin yielded a maximum log of the odds (LOD) score of 2.36 on chromosome S at 20 cM (p=O.0004) in European Americans, and an LOD score of 2.28 on chromosome 19 at 11 cM (p=0.0004) in African Americans. The heritability of fasting serum glucose was 0.5 109±0.08 in the former and 0.29±0.09 in the latter (pcO.0003 for both) after adjusting for age, sex and BMI. A genome-wide scan for fasting serum glucose re- vealed a maximum LOD score of 2.07 on chromosome 5 at 26 cM (p=0.0009) in European Americans. Conclusions/ interpretation: These analyses demonstrate the marked heritability of fasting serum insulin and glucose concentrations in families enriched for the presence of members with hypertension. They suggest that genes associated with fasting serum insulin concentration are present on chromosomes 19 and 5, and that genes associated with fasting serum glucose concentration are on chromosome 5, in families enriched for hypertension.
- Subjects
ESSENTIAL hypertension; AFRICAN Americans; INSULIN; BLOOD sugar; GENOMES; SERUM; GENETICS
- Publication
Diabetologia, 2005, Vol 48, Issue 4, p661
- ISSN
0012-186X
- Publication type
Article
- DOI
10.1007/s00125-005-1679-5