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- Title
Diastereoselective Three-Component 1,3-Dipolar Cycloaddition to Access Functionalized β -Tetrahydrocarboline- and Tetrahydroisoquinoline-Fused Spirooxindoles.
- Authors
Wang, Yongchao; Chen, Yu; Duan, Shengli; Cao, Yiyang; Sun, Wenjin; Zhang, Mei; Zhao, Delin; Hu, Donghua; Dong, Jianwei
- Abstract
A chemselective catalyst-free three-component 1,3-dipolar cycloaddition has been described. The unique polycyclic THPI and THIQs were creatively employed as dipolarophiles, which led to the formation of functionalized β-tetrahydrocarboline- and tetrahydroisoquinoline-fused spirooxindoles in 60–94% of yields with excellent diastereoselectivities (10: 1−>99: 1 dr). This reaction not only realizes a concise THPI- or THIQs-based 1,3-dipolar cycloaddition, but also provides a practical strategy for the construction of two distinctive spirooxindole skeletons.
- Subjects
RING formation (Chemistry); SKELETON; CHEMOSELECTIVITY
- Publication
Molecules, 2024, Vol 29, Issue 8, p1790
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29081790