We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy.
- Authors
Lim, Yan Yik; Zaidi, Ahmad Mujahid Ahmad; Miskon, Azizi
- Abstract
Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands' roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.
- Subjects
UNITED States. Food &; Drug Administration; PLATINUM; OSTEOSARCOMA; ZINC; TREATMENT effectiveness; COPPER; DRUG delivery systems
- Publication
Molecules, 2023, Vol 28, Issue 7, p2920
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28072920