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- Title
Optimization of nutrient parameters for lovastatin production by Monascus purpureus MTCC 369 under submerged fermentation using response surface methodology.
- Authors
Sayyad, Sadik Ali; Panda, Bibhu Prasad; Javed, Saleem; Ali, Mohd
- Abstract
Lovastatin, an inhibitor of HMG-CoA reductase, was produced by submerged fermentation using Monascus purpureus MTCC 369. Five nutritional parameters screened using Plackett–Burman experimental design were optimized by Box–Behnken factorial design of response surface methodology for lovastatin production in shake flask cultures. Maximum lovastatin production of 351 mg/l were predicted in medium containing 29.59 g/l dextrose, 3.86 g/l NH4Cl, 1.73 g/l KH2PO4, 0.86 g/l MgSO4·7H2O, and 0.19 g/l MnSO4·H2O using response surface plots and point prediction tool of DESIGN EXPERT 7.0 (Statease, USA) software.
- Subjects
MONASCUS purpureus; FERMENTATION; EXPERIMENTAL design; FACTORIAL experiment designs; NUTRITION
- Publication
Applied Microbiology & Biotechnology, 2006, Vol 73, Issue 5, p1054
- ISSN
0175-7598
- Publication type
Article
- DOI
10.1007/s00253-006-0577-1