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- Title
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt.
- Authors
Fulton, David; Gratton, Jean-Philippe; McCabe, Timothy J.; Fontana, Jason; Fujio, Yasushi; Walsh, Kenneth; Franke, Thomas F.; Papapetropoulos, Andreas; C. Sessa, William
- Abstract
Presents research which showed that the serine/threonine protein kinase Akt can directly phosphorylate endothelial nitric oxide synthase (eNOS) on serine 1179. Role of eNOS in systems blood pressure, vascular remodeling and angiogenesis; Phosphorylation of eNOS; Traits of mutant eNOS (S1179A); Difference between activated and activation-deficient Akt in nitric oxide production; eNOS being an Akt substrate.
- Subjects
PROTEIN kinases; SERINE proteinases; PHOSPHORYLATION; NITRIC oxide; ANALYTICAL chemistry; BIOCHEMICAL mechanism of action; PHYSIOLOGY
- Publication
Nature, 1999, Vol 399, Issue 6736, p597
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/21218