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- Title
Ratlarda Nikel Sülfatın Genotoksisitesine Karşı Likopenin Koruyucu Etkisi.
- Authors
GARİP, Zozan; TEMAMOĞULLARI, Füsun; KILIÇLE, Pınar AKSU
- Abstract
Aim: Nickel, which has a wide usage area in industries, has teratogenic, carcinogenic, immunotoxic, and genotoxic effects. In this study, the protective effects of lycopene, which has antioxidant properties, were investigated against genotoxicity caused by nickel sulphate. Materials and Methods: In the study, a total of 24 rats (Wistar albino) were divided into four groups: Group I (control) was given daily saline intraperitoneally (i.p.) and corn oil orally by gavage (0.5 ml); Group II was given nickel sulphate (20 mg/kg, i.p.) dissolved in physiological saline; Group III was given lycopene suspended in corn oil (0.5 ml) by oral gavage at 20 mg/kg doses; Group IV was given both lycopene suspended in corn oil (0.5 ml) by oral gavage at 20 mg/kg doses, and 2 hours later, nickel sulphate (20 mg/kg, i.p.) for 21 days. Micronucleated polychromatic erythrocytes (MNPCE) and polychromatic erythrocytes (PCE) were examined by bone marrow micronucleus test, which is one of the genotoxicity tests. Results: It was determined that the administration of lycopene for preventive purposes decreased the MNPCE levels significantly (p<0.001) compared to the nickel sulphate group. Conclusion: Administration of lycopene at a dose of 20 mg/kg is protective against the genotoxic effects of nickel sulphate.
- Subjects
NICKEL; EXPERIMENTAL design; ANIMAL experimentation; MUTAGENICITY testing; LYCOPENE; RATS; DESCRIPTIVE statistics; ERYTHROCYTES; ANIMALS; BONE marrow examination
- Publication
Balikesir Health Sciences Journal / Balıkesir Sağlık Bilimleri Dergisi, 2022, Vol 11, p1
- ISSN
2146-9601
- Publication type
Article
- DOI
10.53424/balikesirsbd.1144724