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- Title
Disruption of IRS-2 causes type 2 diabetes in mice.
- Authors
Withers, Dominic J.; Gutierrez, Julio Sanchez; Towery, Heather; Burks, Deborah J.; Jian-Ming Ren; Previs, Stephen; Zhang, Yitao; Bernal, Dolores; Pons, Sebastian; Shulman, Gerald I.; Bonner-Weir, Susan; White, Morris F.
- Abstract
Presents research which showed that disruption of IRS-2 impairs both peripheral insulin signaling and pancreatic beta-cell function in mice. Symptoms of human type 2 diabetes; Role of insulin-receptor substrates (IRS proteins) in diabetes; Effects of disruption of IRS-2 in mice; Traits of IRS-2-deficient mice; Possibilities for human type 2 diabetes.
- Subjects
INSULIN receptors; TYPE 2 diabetes; PATHOLOGICAL physiology
- Publication
Nature, 1998, Vol 391, Issue 6670, p900
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/36116