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- Title
Light damaging action of all- trans-retinal and its derivatives on rhodopsin molecules in the photoreceptor membrane.
- Authors
Loginova, M. Yu.; Rostovtseva, Ye. V.; Feldman, T. B.; Ostrovsky, M. A.
- Abstract
We have reproduced the model system containing A2-rhodopsin, NR-PE, A2-PE, and ATR-dimer-PE in order to study photosensitized damage of rhodopsin within photoreceptor membranes of rod outer segments. We have demonstrated that irradiation of such a system with visible light (400–700 nm) distorts the most important functional property of native visual pigment—its ability to regenerate after addition of 11- cis-retinal in the dark. We have also shown that all- trans-retinal bound to membrane phospholipids and rhodopsin has less photosensitizing activity that free all- trans-retinal.
- Subjects
RETINOIDS; RHODOPSIN; RETINA; PHOTORECEPTORS; CELL membranes
- Publication
Biochemistry (00062979), 2008, Vol 73, Issue 2, p130
- ISSN
0006-2979
- Publication type
Article
- DOI
10.1134/S000629790802003X