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- Title
Parkinson's disease and nocturnal polyuria.
- Authors
Sakakibara, Ryuji; Shimizu, Ayami; Takahashi, Osamu; Ogata, Tsuyoshi; Sawai, Setsu; Uchiyama, Tomoyuki; Yamamoto, Tatsuya
- Abstract
Background: The question of whether Parkinson's disease (PD) patients have nocturnal polyuria (NP) has not yet been fully answered. Objectives: To determine whether NP was present in PD patients and if so, what its relevant factors were. Methods: This was a retrospective analysis. We had 36 consecutive referred PD patients: age, 71.5 years (range, 54–83 years); 24 men, 12 women; mean disease duration, 2.5 years (1.0–4.5 years); Hoehn and Yahr motor scale, 3.0 (2.0–3.5); all ambulatory; all on treatment. All the PD patients completed a lower urinary tract symptom (LUTS questionnaire) and a bladder diary, and underwent urodynamics testing. Results: NP was identified in 56% of patients. NP was more common in patients with nocturia (p < 0.05), and in patients with urodynamic detrusor overactivity (p < 0.01). There was no relation between NP and gender, age, PD medications, blood pressure, or comorbid diabetes. Conclusions: A total of 56% of PD patients had NP, which had a close relation with detrusor overactivity (p < 0.01). These findings suggest that in PD, the loss of dopaminergic neurons leads to NP (hypothalamic circuit) and detrusor overactivity (nigrostriatal circuit).
- Subjects
NOCTURIA; PARKINSON'S disease; DOPAMINERGIC neurons; DIABETES insipidus; URINARY organs; BLOOD pressure
- Publication
Neurology & Clinical Neuroscience, 2023, Vol 11, Issue 1, p27
- ISSN
2049-4173
- Publication type
Article
- DOI
10.1111/ncn3.12686