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- Title
Recurrence of Drug-Induced Lupus Secondary to Vedolizumab Use in a Patient With Crohn's Disease.
- Authors
Rodriguez, Vanessa I.; Mathavan, Akshay; Mathavan, Akash; Rodriguez, Diana N.; Alvarez, Catalina Sanchez; Pham, Angela
- Abstract
Drug-induced lupus is an autoimmune phenomenon characterized by the development of systemic lupus erythematosus--like clinical features after drug exposure. The entity is a clinical diagnosis. Evaluation consists of recognizing systemic lupus erythematosus-- like features, identifying an appropriate causative agent, observing elevations of characteristic autoantibodies, and obtaining positive response with drug discontinuation. Vedolizumab is an anti-α4β7 antibody used in the treatment of ulcerative colitis and Crohn's disease. We report a novel case of drug-induced lupus recurrence secondary to vedolizumab use in a patient with Crohn's disease, emphasizing diagnostic evaluation, and provide a brief review of the published literature.
- Subjects
CROHN'S disease diagnosis; CROHN'S disease; ULCERATIVE colitis; CLINICAL pathology; INFLAMMATORY bowel diseases; DNA; AZATHIOPRINE; MONOCLONAL antibodies; JOINT pain; INFLIXIMAB; DISEASE relapse; TREATMENT effectiveness; SYSTEMIC lupus erythematosus; PHARMACODYNAMICS; DISEASE risk factors
- Publication
ACG Case Reports Journal, 2024, Vol 11, Issue 1, p1
- ISSN
2326-3253
- Publication type
Article
- DOI
10.14309/crj.0000000000001270