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- Title
Natural killer cells and reproductive health.
- Authors
Chong, Hsu Phern; Quenby, Siobhan M
- Abstract
Key content: Uterine and peripheral natural killer cells have distinct functions.Uterine natural killer cells play an important role in decidualisation and implantation.There is evidence to suggest that disorders in uterine natural killer cell physiology may lead to reproductive problems, such as recurrent miscarriage, recurrent implantation failure and pre‐eclampsia.Current evidence does not support routine testing of uterine natural killer cells and more research is needed. Learning objectives: Distinguish between peripheral and uterine natural killer cells.Counsel women with recurrent pregnancy loss about natural killer cell testing. Ethical issues: Investigation and treatment of women with recurrent miscarriage or recurrent implantation failure is complex. The psychological implications of these conditions may result in a myriad of investigations and treatments of questionable benefit.
- Subjects
PREECLAMPSIA; ANTIGENS; HUMAN reproductive technology; KILLER cells; MENSTRUAL cycle; MISCARRIAGE; MOLECULAR diagnosis; PLACENTA; REPRODUCTIVE health; TREATMENT effectiveness; THERAPEUTICS
- Publication
Obstetrician & Gynaecologist, 2016, Vol 18, Issue 2, p91
- ISSN
1467-2561
- Publication type
Article
- DOI
10.1111/tog.12256