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- Title
Corneal confocal microscopy is efficient, well-tolerated, and reproducible.
- Authors
Smith, Albert Gordon; Kim, Gene; Porzio, Michael; Allen, Blaine; Koach, Margaret; Mifflin, Mark; Digre, Kathleen; Keung, Bonnie M.; Singleton, John Robinson
- Abstract
In order to develop an efficient, reproducible, and well-tolerated protocol for assessing corneal innervation, 11 normal subjects underwent corneal confocal microscopy ( CCM) using a Heidelberg Retinal Tomography III microscope. Five standardized locations were sampled in the left eye and one centrally in the right. The protocol was repeated 1-4 weeks later. A blinded technician measured nerve fiber length ( NFL) and tortuosity coefficient ( TC). The relationship between image location and NFL and TC was assessed using one-way analysis of variance, and reproducibility determined using relative intertrial variability and intraclass correlation coefficients. NFL reproducibility was maximized by averaging four or more images from the left eye, or one central image from both eyes. TC was less reproducible. CCM is a rapid, well-tolerated, and reproducible method for assessing corneal innervation.
- Subjects
ANALYSIS of variance; CONFIDENCE intervals; CORNEA; STATISTICAL correlation; MEDICAL protocols; MICROSCOPY; NEURONS; RESEARCH evaluation; RESEARCH funding; STATISTICS; T-test (Statistics); DATA analysis; REPEATED measures design; DATA analysis software; DESCRIPTIVE statistics; INNERVATION; ANATOMY
- Publication
Journal of the Peripheral Nervous System, 2013, Vol 18, Issue 1, p54
- ISSN
1085-9489
- Publication type
Article
- DOI
10.1111/jns5.12008