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- Title
Microvasculitic paraproteinaemic polyneuropathy and B-cell lymphoma.
- Authors
Turner, Martin R.; Warren, Jason D.; Jacobs, Jean M.; Groves, Mike J.; Yong, Kwee; Honan, William P.; Thomas, P. K.; Reilly, and Mary M.
- Abstract
Abstract Microvasculitis may play a greater part in the pathogenesis of paraproteinaemic neuropathies than is generally recognised, producing tissue destruction by convergent immune and physical mechanisms. We present a patient with a clinical syndrome of mononeuritis multiplex and a circulating IgM lambda paraprotein, in whom bone marrow aspiration revealed a lymphoplasmacytoid lymphoma. Microvasculitic changes were present in the first nerve biopsy, and the second showed extensive destruction of neural architecture and deposition of IgM-related material. A 2-stage pathogenic cascade is postulated and explored with a review of the relevant literature.
- Subjects
NEUROPATHY; B cells; PARAPROTEINEMIA; HEMATOPOIETIC system
- Publication
Journal of the Peripheral Nervous System, 2003, Vol 8, Issue 2, p100
- ISSN
1085-9489
- Publication type
Article
- DOI
10.1046/j.1529-8027.2003.03013.x