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- Title
Subanesthetic-Dose Ketamine to Decrease Emergence Delirium in the Surgical Patient With Posttraumatic Stress Disorder.
- Authors
Hintzsche, Kristina
- Abstract
Recently, emergence delirium (ED) has been associated with patients with posttraumatic stress disorder (PTSD). Currently, no research exists to support best practice in this population. Identification of the pathophysiologic alterations that occur in ED and PTSD can guide pharmacotherapy. Emerging evidence suggests that glutaminergic dysfunction plays a role in ED and PTSD. A comprehensive understanding of the glutaminergic alterations that occur in ED and PTSD exposes a potential for pharmacologic intervention. The anesthetic agent ketamine modulates glutamate neurotransmission via N-methyl-D-aspartate (NMDA) receptor antagonism. By appreciating the relationship that exists between ED, PTSD, and glutamate, one can extrapolate that a subanesthetic dose of ketamine may decrease ED in the surgical patient with PTSD.
- Subjects
RISK of delirium; DELIRIUM; DRUGS; GLUTAMINE; KETAMINE; NEUROTRANSMITTERS; PATIENTS; POST-traumatic stress disorder; SURGERY; PHARMACODYNAMICS; PREVENTION
- Publication
AANA Journal, 2018, Vol 86, Issue 3, p220
- ISSN
0094-6354
- Publication type
Article