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- Title
Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results.
- Authors
Xu, Biao; Tu, Bo; Chu, Fang; Jalloh, Mohamed; Mu, Jin-Song; Zheng, Jun-Jie; Chen, Wei-Wei
- Abstract
Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization (WHO) product testing summary and discuss the causes of false-negative (FN) results with a focus on low parasite density, improper RDT storage, operation and interpretation, and plasmodium falciparum with a pfhrp2/3 gene deletion. The results demonstrated that the malaria RDTs currently commercially available might cause FN results in practice.
- Subjects
WORLD Health Organization; COMMERCIAL product testing; DIAGNOSIS methods; MALARIA; SECONDARY analysis; DELETION mutation; PLASMODIUM falciparum
- Publication
Military Medical Research, 2021, Vol 8, Issue 1, p1
- ISSN
2095-7467
- Publication type
Letter
- DOI
10.1186/s40779-021-00345-0