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- Title
Glucose-Sensitive Hydrogels for the Controlled Release of Insulin.
- Authors
Valuev, L. I.; Valuev, I. L.; Vanchugova, L. V.; Obydennova, I. V.
- Abstract
Hydrogels with an increased content of fine pores are synthesized via the copolymerization of acrylamide with N-(2-D-glucose) acrylamide and N,N-methylenebis(acrylamide) in the presence of concanavalin A and mercaptoacetic acid. Insulin introduced into the hydrogels is spontaneously released in response to increase in the concentration of glucose in the environment via a two-step mechanism similar to that in the case of the pancreas and the maximum rate is observed at the first stage.
- Subjects
HYDROGELS; POLYMER colloids; INSULIN synthesis; INSULIN structure; INSULIN resistance; THERAPEUTICS
- Publication
Polymer Science -- Series A, 2018, Vol 60, Issue 4, p495
- ISSN
0965-545X
- Publication type
Article
- DOI
10.1134/S0965545X18040132