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- Title
Thyroidectomy for amiodarone-induced thyrotoxicosis.
- Authors
Farwell, A P; Abend, S L; Huang, S K; Patwardhan, N A; Braverman, L E
- Abstract
Amiodarone hydrochloride, an iodine-rich drug used in the treatment of tachyarrhythmias, is responsible for the development of thyrotoxicosis in approximately 10% of patients who reside in areas of moderate iodine deficiency. Treatment of amiodarone-induced thyrotoxicosis is difficult since the drug has a prolonged half-life, cardiac decompensation due to underlying heart disease occurs often, and discontinuation of amiodarone therapy may not be possible. We report a patient with severe thyrotoxicosis who received amiodarone for 34 months. Prolonged treatment with methimazole, potassium perchlorate, iopanoic acid, and dexamethasone was unsuccessful in controlling the hyperthyroid state. A near-total thyroidectomy resulted in rapid amelioration of thyrotoxicosis. Since surgery results in rapid control of thyrotoxicosis and permits continued therapy with amiodarone, we suggest that near-total thyroidectomy warrants consideration as definitive treatment for resistant amiodarone-induced thyrotoxicosis.
- Subjects
AMIODARONE; COMPARATIVE studies; HYPERTHYROIDISM; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; THYROID gland function tests; THYROIDECTOMY; EVALUATION research
- Publication
JAMA: Journal of the American Medical Association, 1990, Vol 263, Issue 11, p1526
- ISSN
0098-7484
- Publication type
journal article
- DOI
10.1001/jama.263.11.1526