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- Title
Sildenafil, nifedipine and acetazolamide do not allow for blood flow through intrapulmonary arteriovenous anastomoses during exercise while breathing 100% oxygen.
- Authors
Elliott, Jonathan E.; Friedman, Jonathan M.; Futral, Joel E.; Goodman, Randall D.; Lovering, Andrew T.
- Abstract
New Findings What is the central question of this study? Compared with exercise while breathing room air, blood flow through intrapulmonary arteriovenous anastomoses during exercise while breathing 100% O2 is prevented/reduced, presumably due to vasoconstriction of these vessels. We sought to investigate the effect of sildenafil, nifedipine and acetazolamide, which are known modulators of pulmonary vascular tone, on the hyperoxia-induced reduction in blood flow through intrapulmonary arteriovenous anastomoses during exercise., What is the main finding and its importance? We show that,independently, sildenafil, nifedipine and acetazolamide do not prevent the hyperoxia-induced reduction in blood flow through intrapulmonary arteriovenous anastomoses during exercise. These data provide the first insight into the regulation of intrapulmonary arteriovenous anastomoses during exercise while breathing 100% O2., Blood flow through intrapulmonary arteriovenous anastomoses (IPAVAs) is known to increase in healthy humans during exercise while breathing room air, but is prevented or significantly reduced during exercise while breathing 100% O2, potentially due to vasoconstriction of IPAVAs. Thus, pharmacological interventions that target known pathways regulating the cardiopulmonary circulation may be able to prevent the hyperoxia-induced reduction in IPAVA blood flow (
- Subjects
BLOOD flow; OXYGEN; RESPIRATION; ARTERIOVENOUS anastomosis; EXERCISE; SILDENAFIL; NIFEDIPINE; ACETAZOLAMIDE
- Publication
Experimental Physiology, 2014, Vol 99, Issue 12, p1636
- ISSN
0958-0670
- Publication type
Article
- DOI
10.1113/expphysiol.2014.081562