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- Title
Cerebellum/liver index on baseline 18F-FDG PET/CT to improve prognostication in post-transplant lymphoproliferative disorders: a multicenter retrospective study.
- Authors
Morland, David; Kanagaratnam, Lukshe; Hubelé, Fabrice; Toussaint, Elise; Choquet, Sylvain; Kas, Aurélie; Caquot, Pierre-Ambroise; Haioun, Corinne; Itti, Emmanuel; Leprêtre, Stéphane; Decazes, Pierre; Bijou, Fontanet; Schwartz, Paul; Jacquet, Caroline; Chauchet, Adrien; Matuszak, Julien; Kamar, Nassim; Payoux, Pierre; Renaud, Loïc; Vercellino, Laetitia
- Abstract
Background: Besides International Prognostic Index (IPI) score, baseline prognostic factors of post-transplant lymphoproliferative disorders (PTLD) are poorly identified due to the rarity of the disease. New indexes derived from healthy organ uptake in baseline 18F-FDG PET/CT have been studied in immunocompetent lymphoma patients. The aim of this study is to evaluate the performances of the cerebellum-to-liver uptake ratio (denoted as CLIP) as a prognostic factor for PFS and OS. This retrospective multicenter study is based on patients with PTLD included in the K-VIROGREF cohort. The previously published threshold of 3.24 was used for CLIP in these analyses. Results: A total of 97 patients was included with a majority of monomorphic diffuse large B-cell lymphoma subtype (78.3%). Both IPI score (≥ 3) and CLIP (< 3.24) were significant risk factors of PFS with corresponding hazard ratios of 2.0 (1.0–4.0) and 2.4 (1.3–4.5) respectively. For OS, CLIP was not significant and resulted in a hazard ratio of 2.6 (p = 0.059). Neither IPI score or Total Metabolic Tumor Volume reached significance for OS. Conclusion: CLIP is a promising predictor of PFS and perhaps OS in PTLD. Further prospective studies are needed to confirm these results.
- Subjects
LYMPHOPROLIFERATIVE disorders; DIFFUSE large B-cell lymphomas; CEREBELLUM; FLUORODEOXYGLUCOSE F18; PROGNOSIS
- Publication
EJNMMI Research, 2024, Vol 14, Issue 1, p1
- ISSN
2191-219X
- Publication type
Article
- DOI
10.1186/s13550-024-01111-8