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- Title
Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA.
- Authors
Williams, Courtney; Chen, Wenyan; Lee, Chia-Hsueh; Yaeger, Daniel; Vyleta, Nicholas P; Smith, Stephen M
- Abstract
Voltage-activated Ca2+ channels (VACCs) mediate Ca2+ influx to trigger action potential-evoked neurotransmitter release, but the mechanism by which Ca2+ regulates spontaneous transmission is unclear. We found that VACCs are the major physiological triggers for spontaneous release at mouse neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type.
- Subjects
CALCIUM channels; GABA; NEUROTRANSMITTER receptors; ACTION potentials; EXCITATORY amino acids
- Publication
Nature Neuroscience, 2012, Vol 15, Issue 9, p1195
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.3162