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- Title
The functional asymmetry of auditory cortex is reflected in the organization of local cortical circuits.
- Authors
Oviedo, Hysell V.; Bureau, Ingrid; Svoboda, Karel; Zador, Anthony M.
- Abstract
The primary auditory cortex (A1) is organized tonotopically, with neurons sensitive to high and low frequencies arranged in a rostro-caudal gradient. We used laser scanning photostimulation in acute slices to study the organization of local excitatory connections onto layers 2 and 3 (L2/3) of the mouse A1. Consistent with the organization of other cortical regions, synaptic inputs along the isofrequency axis (orthogonal to the tonotopic axis) arose predominantly within a column. By contrast, we found that local connections along the tonotopic axis differed from those along the isofrequency axis: some input pathways to L3 (but not L2) arose predominantly out-of-column. In vivo cell-attached recordings revealed differences between the sound-responsiveness of neurons in L2 and L3. Our results are consistent with the hypothesis that auditory cortical microcircuitry is specialized to the one-dimensional representation of frequency in the auditory cortex.
- Subjects
AUDITORY cortex; TEMPORAL lobe; NERVOUS system abnormalities; CEREBRAL dominance; CELLS; NERVOUS system
- Publication
Nature Neuroscience, 2010, Vol 13, Issue 11, p1413
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.2659