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- Title
Chimeric Antigen Receptors for T-Cell Malignancies.
- Authors
Scherer, Lauren D.; Brenner, Malcolm K.; Mamonkin, Maksim
- Abstract
Development of chimeric antigen receptor (CAR)-modified T cells for the treatment of T-lineage leukemia and lymphoma has encountered several unique challenges. The most widely expressed tumor antigen targets for malignant T cells are often also expressed on non-malignant T cells. Transducing T cells with CARs targeted to these shared antigens can therefore promote over-activation or fratricide of CAR T cells, reducing their therapeutic potency. If fratricide is resolved, clinical CAR T cell activity may eliminate normal T-cell subsets and cause temporary immunosuppression. In this review, we summarize the preclinical development of CAR-based therapies for T-cell malignancies and discuss strategies to minimize toxicities associated with on-target fratricide and off-tumor activity.
- Subjects
CHIMERIC antigen receptors; T cells; FRATRICIDE; IMMUNOSUPPRESSION; LYMPHOMAS
- Publication
Frontiers in Oncology, 2019, pN.PAG
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2019.00126