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- Title
Gene therapy in transplantation.
- Authors
Giannoukakis, N; Thomson, A W; Robbins, P D
- Abstract
Facilitation of solid organ and cell transplantation depends on metabolic and immunologic factors that can be manipulated ex vivo and in vivo using gene transfer technology. Vectors have been developed which can optimally transfer relevant genes to various tissues and organs. Interventions aimed at promoting tissue preservation before transplantation, prevention of oxidative stress and immunological rejection have recently become attractive options using viral and nonviral gene delivery vehicles. Further understanding of the mechanisms involved in tolerance induction as well as the facilitation of xenogeneic engraftment have made possible a variety of avenues that can be exploited using gene transfer technology.
- Subjects
TRANSPLANTATION of organs, tissues, etc.; GENE therapy; HOMOGRAFTS; GRAFT rejection
- Publication
Gene Therapy, 1999, Vol 6, Issue 9, p1499
- ISSN
0969-7128
- Publication type
Article
- DOI
10.1038/sj.gt.3300981