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- Title
Lessons from Lumiracoxib: Are cyclooxygenase-2 inhibitors less hepatotoxic than non-selective non-steroidal anti-inflammatory drugs?
- Authors
Chitturi, Shivakumar; Farrell, Geoffrey C
- Abstract
The authors reflect on the hepatotoxicity of cyclooxygenase-2 (COX-2) inhibitor. They relate the study by P. I. Pillans and colleagues regarding the case of three women who developed severe hepatotoxicity with lumiracoxib and suffered from liver failure and injury. They cite that COX-2 inhibitors are less likely to cause hepatic damage than non-selective non-steroidal anti-inflammatory drugs (NSAIDs).
- Subjects
EDITORIALS; HEPATOTOXICOLOGY; CYCLOOXYGENASE 2 inhibitors; LIVER failure; LIVER injuries; NONSTEROIDAL anti-inflammatory agents
- Publication
Journal of Gastroenterology & Hepatology, 2012, Vol 27, Issue 6, p993
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/j.1440-1746.2012.07142.x