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- Title
Helicobacter pylori in peptic ulcer and gastritis Simplified <sup>13</sup>C-urea breath test with a new infrared spectrometer for diagnosis of Helicobacter pylori infection.
- Authors
Tseng-Shing Chen, Patrizia; Full-Young Chang; Pang-Chi Chen, Patrizia; Huang, Thomas W.; Ou, Jonathan T.; Ming-Hung Tsai, Jonathan T.; Ming-Shiang Wu; Jaw-Town Lin
- Abstract
Infrared spectrometry has correlated excellently with mass spectrometry in detecting the ratio of 13CO2 to 12CO2 in breath samples. The present study aimed to evaluate the accuracy of the 13C-urea breath test (13C-UBT) using a new model of infrared analyzer. A total of 600 patients who were undergoing upper endoscopy without receiving eradication therapy were entered into the study. Culture, histology, and rapid urease test on biopsies from the antrum and corpus of the stomach were used for the determination of Helicobacter pylori infection . Breath samples were collected before and 20 min after drinking 100 mg 13C-urea in 100 mL water. The optimal cutoff value was determined by the receiver operating characteristic curve. Of the 586 patients who were eligible for analysis, 369 were positive for H. pylori infection, 185 were negative for H. pylori infection, and 32 were indeterminate. When the appropriate cutoff value was set at 3.5‰, a sensitivity of 97.8%, a specificity of 96.8% and an accuracy of 97.5% were obtained using the 13C-UBT. The accuracy of the 13C-UBT decreased when CO2 concentration in the breath sample was <2%, as compared with ≥2% (93.6% vs 97.7%), mainly because of a decrease in specificity (81.8% vs 97.7%). There were 2.7% of patients with Δ13CO2 values that fell between 3.0–4.5‰, in whom the risk of error was 47%. The 13C-UBT performed with infrared spectrometry is a highly sensitive, specific, and non-invasive method for the detection of H. pylori infection. The immediate availability of the test result and technical simplicity make it particularly effective in routine clinical practice.
- Subjects
BREATH tests; INFRARED spectroscopy; MASS spectrometry; HELICOBACTER pylori infections
- Publication
Journal of Gastroenterology & Hepatology, 2003, Vol 18, Issue 11, p1237
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1046/j.1440-1746.2003.03139.x