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- Title
Mixed cryoglobulinaemia associated with hepatitis C virus infection: A predictor factor for treatment with interferon?
- Authors
Leone, N; Pellicano, Rinaldo; Marietti, Giorgio; Leone, Nicola; Arena, Vincenzo; Palmas, Franco; Rizzetto, Mario; Ponzetto, Antonio
- Abstract
AbstractBackground and Aims: Mixed cryoglobulinaemia (MC) is a frequent finding among patients infected with hepatitis C virus (HCV). The response to treatment with alpha-interferon (α-IFN) in these patients is linked to predictive factors. The aim of this study was to ascertain whether the presence of MC was a predictive factor of response in patients treated with α-IFN for chronic hepatitis due to HCV. Methods: Thirty-two patients with MC and HCV infection (24 with chronic hepatitis and eight with cirrhosis) were compared with 30 patients with HCV infection without MC (23 chronic hepatitis, seven cirrhosis) of a similar mean age. All were treated with lymphoblastoid α-IFN, at 3 MU, t.i.w., for 6–12 months and then followed up. Results: No statistical difference was observed between the two groups in terms of sustained response (P = 0.83), relapse (P = 0.88) and non-response (P = 0.92). The mean follow up was 24.3 months (range 17–28) for patients with sustained response and for the patients with MC and 22.6 months (range 15–26) for patients without MC. Conclusions: The presence of cryoglobulinaemia does not influence the response to α-IFN in patients with chronic HCV infection. © 1999 Blackwell Science Asia Pty Ltd.
- Subjects
HEPATITIS C treatment; INTERFERONS; CRYOGLOBULINEMIA
- Publication
Journal of Gastroenterology & Hepatology, 1999, Vol 14, Issue 11, p1108
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1046/j.1440-1746.1999.02015.x