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- Title
SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 1, 2, 4 TRIAZOLE DERIVATIVES CONTAINING THIAZOLIDINONE.
- Authors
Wakale, V. S.; Pattan, S. R.
- Abstract
A series of 2-(4-substituted)-5-mercapto-4H-1,2,4-triazol-3-yl)phenol (3a-3f) and 3-(3-(2- hydroxyphenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)-2-substituted thiazolidin-4-one (4a-4f) was designed and synthesized. The synthesized compounds were characterized by IR, ¹H-NMR and elemental analysis. The synthesized compounds were evaluated for antibacterial activity by using cup plate agar diffusion method against Escherichia coli and Staphylococcus aureus, antifungal activity against Aspergillusnigerand Candida albicans. Compounds 3c, 4d, and 4f showed potent inhibition against all the bacterial and fungal strains.
- Subjects
TRIAZOLE derivatives; ANTI-infective agents; THIAZOLE derivatives
- Publication
International Journal of Pharmaceutical, Chemical & Biological Sciences, 2015, Vol 5, Issue 3, p561
- ISSN
2249-9504
- Publication type
Article