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- Title
Recurrent Cancer of the Vulva: Clinicopathologic Prognostic Factors, Patterns of Recurrence, and Their Management.
- Authors
Batra Modi, Kanika; Sekhon, Rupinder; Shah, Swati; Giri, Shweta; Jain, Vandana; Mitra, Swarupa; Rawal, Sudhir
- Abstract
Objective: The aims of this study were to analyze the clinicopathologic parameters and patterns of recurrence in vulvar cancers at a tertiary cancer center and to evaluate their prognostic implications. Given the rarity of these tumors, the information regarding prognostic factors involving recurrent cases is limited and conflicting. Materials and Methods: The records of all patients with vulvar cancer who underwent primary surgery from January 2007 to December 2014 were analyzed. Information regarding each patient's demography, clinical findings, treatment given, complications, and follow-up details was collected for this retrospective study. Results: Seventy-eight patients were included in this analysis. Seventeen patients (21.7%) had recurrent disease after a mean interval of 15 months. Nodal status, tumor classification, depth of invasion, lymphovascular space invasion, and resection margin were statistically significant prognostic factors for disease-free and overall survivors according to a univariate analysis. On multivariate analysis, only tumor size, nodal positivity, and margin status appeared to be statistically significant. Conclusions: Clinicopathologic patterns could help stratify patients for adjuvant radiotherapy of the vulva. Intensified vulvoscopic follow-up is needed to prevent multiple local recurrences, especially those with high-risk prognostic factors. This study suggests the value of giving local vulvar radiation to patients in high-risk groups to prevent local recurrences. Customized and strategic management of recurrences is needed according to the pattern of recurrence. (J GYNECOL SURG 32:339)
- Subjects
CANCER relapse; CANCER invasiveness; MULTIVARIATE analysis; STATISTICS; VULVA; VULVAR tumors; RETROSPECTIVE studies; DESCRIPTIVE statistics; TERTIARY care; PROGNOSIS; PREVENTION
- Publication
Journal of Gynecologic Surgery, 2016, Vol 32, Issue 6, p339
- ISSN
1042-4067
- Publication type
Article
- DOI
10.1089/gyn.2016.0049